Human CARD9 activation kit by CRISPRa

CAT#: GA112004

CARD9 CRISPRa kit - CRISPR gene activation of human caspase recruitment domain family member 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CARD9
• Locus ID: 64170
• Kit Components:

  GA112004G1, CARD9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112004G2, CARD9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112004G3, CARD9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022352, NM_052813, NM_052814
• Synonyms: caspase recruitment domain family, member 9; caspase recruitment domain protein 9; hCARD9; OTTHUMP00000022571
• Summary: The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]