Human LEPRE1 (P3H1) activation kit by CRISPRa

CAT#: GA112007

P3H1 CRISPRa kit - CRISPR gene activation of human prolyl 3-hydroxylase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: P3H1
• Locus ID: 64175
• Kit Components:

  GA112007G1, P3H1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112007G2, P3H1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112007G3, P3H1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146289, NM_001243246, NM_022356
• Synonyms: GROS1; LEPRE1; OI8
• Summary: This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]