Human Dectin 1 (CLEC7A) activation kit by CRISPRa

CAT#: GA112091

CLEC7A CRISPRa kit - CRISPR gene activation of human C-type lectin domain containing 7A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLEC7A
• Locus ID: 64581
• Kit Components:

  GA112091G1, CLEC7A gRNA vector 1 in pCas-Guide-CRISPRa

  GA112091G2, CLEC7A gRNA vector 2 in pCas-Guide-CRISPRa

  GA112091G3, CLEC7A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022570, NM_197947, NM_197948, NM_197949, NM_197950, NM_197951, NM_197952, NM_197953, NM_197954, NR_125336
• Synonyms: BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2
• Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]