Human VPS16 activation kit by CRISPRa

CAT#: GA112097

VPS16 CRISPRa kit - CRISPR gene activation of human VPS16 core subunit of CORVET and HOPS complexes

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPS16
• Locus ID: 64601
• Kit Components:

  GA112097G1, VPS16 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112097G2, VPS16 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112097G3, VPS16 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022575, NM_080413, NM_080414
• Synonyms: hVPS16
• Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]