Human PDI (PDIA2) activation kit by CRISPRa

CAT#: GA112110

PDIA2 CRISPRa kit - CRISPR gene activation of human protein disulfide isomerase family A member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDIA2
• Locus ID: 64714
• Kit Components:

  GA112110G1, PDIA2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112110G2, PDIA2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112110G3, PDIA2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006849
• Synonyms: PDA2; PDI; PDIP; PDIR
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]