Human FNDC4 activation kit by CRISPRa

CAT#: GA112165

FNDC4 CRISPRa kit - CRISPR gene activation of human fibronectin type III domain containing 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FNDC4
• Locus ID: 64838
• Kit Components:

  GA112165G1, FNDC4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112165G2, FNDC4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112165G3, FNDC4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022823
• Synonyms: FRCP1
• Summary: Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. [UniProtKB/Swiss-Prot Function]