Human Axotrophin (MARCH7) activation kit by CRISPRa

CAT#: GA112170

MARCH7 CRISPRa kit - CRISPR gene activation of human membrane associated ring-CH-type finger 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARCH7
• Locus ID: 64844
• Kit Components:

  GA112170G1, MARCH7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112170G2, MARCH7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112170G3, MARCH7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282805, NM_001282806, NM_001282807, NM_022826
• Synonyms: AXO; AXOT; MARCH-VII; RNF177
• Summary: MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]). [supplied by OMIM, Mar 2010]