Human CTIP2 (BCL11B) activation kit by CRISPRa

CAT#: GA112193

BCL11B CRISPRa kit - CRISPR gene activation of human BAF chromatin remodeling complex subunit BCL11B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL11B
• Locus ID: 64919
• Kit Components:

  GA112193G1, BCL11B gRNA vector 1 in pCas-Guide-CRISPRa

  GA112193G2, BCL11B gRNA vector 2 in pCas-Guide-CRISPRa

  GA112193G3, BCL11B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282237, NM_001282238, NM_022898, NM_138576
• Synonyms: ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; RIT1; ZNF856B
• Summary: This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]