Human WNK1 activation kit by CRISPRa

CAT#: GA112245

WNK1 CRISPRa kit - CRISPR gene activation of human WNK lysine deficient protein kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: WNK1
• Locus ID: 65125
• Kit Components:

  GA112245G1, WNK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112245G2, WNK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112245G3, WNK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184985, NM_014823, NM_018979, NM_213655, N57692
• Synonyms: HSAN2; HSN2; KDP; p65; PPP1R167; PRKWNK1; PSK
• Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined. [provided by RefSeq, May 2010]