Human WNK4 activation kit by CRISPRa

CAT#: GA112258

WNK4 CRISPRa kit - CRISPR gene activation of human WNK lysine deficient protein kinase 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: WNK4
• Locus ID: 65266
• Kit Components:

  GA112258G1, WNK4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112258G2, WNK4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112258G3, WNK4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321299, NM_032387
• Synonyms: PHA2B; PRKWNK4
• Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. [provided by RefSeq, Sep 2009]