Human VKORC1 activation kit by CRISPRa

CAT#: GA112301

VKORC1 CRISPRa kit - CRISPR gene activation of human vitamin K epoxide reductase complex subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VKORC1
• Locus ID: 79001
• Kit Components:

  GA112301G1, VKORC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112301G2, VKORC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112301G3, VKORC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001311311, NM_024006, NM_206824
• Synonyms: EDTP308; MST134; MST576; VKCFD2; VKOR
• Summary: This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]