Human TSEN34 activation kit by CRISPRa

CAT#: GA112332

TSEN34 CRISPRa kit - CRISPR gene activation of human tRNA splicing endonuclease subunit 34

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSEN34
• Locus ID: 79042
• Kit Components:

  GA112332G1, TSEN34 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112332G2, TSEN34 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112332G3, TSEN34 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077446, NM_001282332, NM_001282333, NM_024075
• Synonyms: LENG5; PCH2C; SEN34; SEN34L
• Summary: This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]