Human KREMEN2 activation kit by CRISPRa

CAT#: GA112439

KREMEN2 CRISPRa kit - CRISPR gene activation of human kringle containing transmembrane protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KREMEN2
• Locus ID: 79412
• Kit Components:

  GA112439G1, KREMEN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112439G2, KREMEN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112439G3, KREMEN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001253725, NM_001253726, NM_024507, NM_145347, NM_145348, NM_172229
• Synonyms: KRM2
• Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]