Human HRPT2 (CDC73) activation kit by CRISPRa

CAT#: GA112467

CDC73 CRISPRa kit - CRISPR gene activation of human cell division cycle 73

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC73
• Locus ID: 79577
• Kit Components:

  GA112467G1, CDC73 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112467G2, CDC73 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112467G3, CDC73 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024529
• Synonyms: C1orf28; FIHP; HPTJT; HRPT1; HRPT2; HYX
• Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]