Human RIC3 activation kit by CRISPRa

CAT#: GA112486

RIC3 CRISPRa kit - CRISPR gene activation of human RIC3 acetylcholine receptor chaperone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RIC3
• Locus ID: 79608
• Kit Components:

  GA112486G1, RIC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112486G2, RIC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112486G3, RIC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135109, NM_001206671, NM_001206672, NM_024557, NR_045405, NM_001346690, NM_001346691, NM_001346692, NM_001346693, NM_001346694, NR_144484, NR_144485, NR_144497
• Synonyms: AYST720; PRO1385
• Summary: This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]