Human C16orf57 (USB1) activation kit by CRISPRa

CAT#: GA112519

USB1 CRISPRa kit - CRISPR gene activation of human U6 snRNA biogenesis phosphodiesterase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: USB1
• Locus ID: 79650
• Kit Components:

  GA112519G1, USB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112519G2, USB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112519G3, USB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195302, NM_001204911, NM_001330568, NM_001330569, NM_024598
• Synonyms: C16orf57; hUsb1; HVSL1; Mpn1; PN
• Summary: This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]