Human STEAP4 activation kit by CRISPRa

CAT#: GA112549

STEAP4 CRISPRa kit - CRISPR gene activation of human STEAP4 metalloreductase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STEAP4
• Locus ID: 79689
• Kit Components:

  GA112549G1, STEAP4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112549G2, STEAP4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112549G3, STEAP4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001205315, NM_001205316, NM_024636
• Synonyms: STAMP2; TIARP; TNFAIP9
• Summary: The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]