Human TBLR1 (TBL1XR1) activation kit by CRISPRa

CAT#: GA112573

TBL1XR1 CRISPRa kit - CRISPR gene activation of human transducin beta like 1 X-linked receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TBL1XR1
• Locus ID: 79718
• Kit Components:

  GA112573G1, TBL1XR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112573G2, TBL1XR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112573G3, TBL1XR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321193, NM_001321194, NM_001321195, NM_024665
• Synonyms: C21; DC42; IRA1; MRD41; TBLR1
• Summary: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]