Human Lin28 (LIN28A) activation kit by CRISPRa

CAT#: GA112581

LIN28A CRISPRa kit - CRISPR gene activation of human lin-28 homolog A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LIN28A
• Locus ID: 79727
• Kit Components:

  GA112581G1, LIN28A gRNA vector 1 in pCas-Guide-CRISPRa

  GA112581G2, LIN28A gRNA vector 2 in pCas-Guide-CRISPRa

  GA112581G3, LIN28A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_024674
• Synonyms: CSDD1; LIN-28; lin-28A; LIN28; ZCCHC1
• Summary: This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]