Human FBXO31 activation kit by CRISPRa

CAT#: GA112628

FBXO31 CRISPRa kit - CRISPR gene activation of human F-box protein 31

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBXO31
• Locus ID: 79791
• Kit Components:

  GA112628G1, FBXO31 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112628G2, FBXO31 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112628G3, FBXO31 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282683, NM_024735, NR_024568
• Synonyms: FBX14; Fbx31; FBXO14; MRT45; pp2386
• Summary: This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]