Human PANK2 activation kit by CRISPRa

CAT#: GA112799

PANK2 CRISPRa kit - CRISPR gene activation of human pantothenate kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PANK2
• Locus ID: 80025
• Kit Components:

  GA112799G1, PANK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112799G2, PANK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112799G3, PANK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001324191, NM_001324192, NM_001324193, NM_024960, NM_153637, NM_153638, NM_153639, NM_153640, NM_153641, NR_136715
• Synonyms: C20orf48; HARP; HSS; NBIA1; PKAN
• Summary: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]