Human HSD3B7 activation kit by CRISPRa

CAT#: GA112898

HSD3B7 CRISPRa kit - CRISPR gene activation of human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HSD3B7
• Locus ID: 80270
• Kit Components:

  GA112898G1, HSD3B7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112898G2, HSD3B7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112898G3, HSD3B7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142777, NM_001142778, NM_025193
• Synonyms: CBAS1; PFIC4; SDR11E3
• Summary: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]