Human MED28 activation kit by CRISPRa

CAT#: GA112908

MED28 CRISPRa kit - CRISPR gene activation of human mediator complex subunit 28

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MED28
• Locus ID: 80306
• Kit Components:

  GA112908G1, MED28 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112908G2, MED28 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112908G3, MED28 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025205
• Synonyms: 1500003D12Rik; EG1; magicin
• Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. [UniProtKB/Swiss-Prot Function]