Human ULBP2 activation kit by CRISPRa

CAT#: GA112927

ULBP2 CRISPRa kit - CRISPR gene activation of human UL16 binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ULBP2
• Locus ID: 80328
• Kit Components:

  GA112927G1, ULBP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112927G2, ULBP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112927G3, ULBP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025217
• Synonyms: ALCAN-alpha; N2DL2; NKG2DL2; RAET1H
• Summary: This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]