Human KCNIP4 activation kit by CRISPRa

CAT#: GA112931

KCNIP4 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel interacting protein 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNIP4
• Locus ID: 80333
• Kit Components:

  GA112931G1, KCNIP4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112931G2, KCNIP4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112931G3, KCNIP4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001035003, NM_001035004, NM_025221, NM_147181, NM_147182, NM_147183, NM_001363504
• Synonyms: CALP; KCHIP4
• Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]