Human PD L2 (PDCD1LG2) activation kit by CRISPRa

CAT#: GA112945

PDCD1LG2 CRISPRa kit - CRISPR gene activation of human programmed cell death 1 ligand 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDCD1LG2
• Locus ID: 80380
• Kit Components:

  GA112945G1, PDCD1LG2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112945G2, PDCD1LG2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112945G3, PDCD1LG2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_025239
• Synonyms: B7DC; bA574F11.2; Btdc; CD273; PD-L2; PDCD1L2; PDL2
• Summary: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. [UniProtKB/Swiss-Prot Function]