Human NPL activation kit by CRISPRa

CAT#: GA113008

NPL CRISPRa kit - CRISPR gene activation of human N-acetylneuraminate pyruvate lyase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPL
• Locus ID: 80896
• Kit Components:

  GA113008G1, NPL gRNA vector 1 in pCas-Guide-CRISPRa

  GA113008G2, NPL gRNA vector 2 in pCas-Guide-CRISPRa

  GA113008G3, NPL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001200050, NM_001200051, NM_001200052, NM_001200056, NM_030769
• Synonyms: C1orf13; C112; NAL; NPL1
• Summary: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]