Human PVRL4 (NECTIN4) activation kit by CRISPRa

CAT#: GA113085

NECTIN4 CRISPRa kit - CRISPR gene activation of human nectin cell adhesion molecule 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NECTIN4
• Locus ID: 81607
• Kit Components:

  GA113085G1, NECTIN4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113085G2, NECTIN4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113085G3, NECTIN4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_030916
• Synonyms: EDSS1; LNIR; nectin-4; PRR4; PVRL4
• Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. [provided by RefSeq, Jan 2011]