Human TMEM49 (VMP1) activation kit by CRISPRa

CAT#: GA113107

VMP1 CRISPRa kit - CRISPR gene activation of human vacuole membrane protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VMP1
• Locus ID: 81671
• Kit Components:

  GA113107G1, VMP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113107G2, VMP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113107G3, VMP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329394, NM_001329395, NM_001329396, NM_001329397, NM_001329398, NM_001329399, NM_001329400, NM_001329401, NM_001329402, NM_030938
• Synonyms: EPG3; TANGO5; TMEM49
• Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]