Human MAD3 (MXD3) activation kit by CRISPRa

CAT#: GA113179

MXD3 CRISPRa kit - CRISPR gene activation of human MAX dimerization protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MXD3
• Locus ID: 83463
• Kit Components:

  GA113179G1, MXD3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113179G2, MXD3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113179G3, MXD3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142935, NM_031300
• Synonyms: BHLHC13; MAD3; MYX
• Summary: This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described. [provided by RefSeq, Dec 2008]