Human RHNO1 activation kit by CRISPRa

CAT#: GA113237

RHNO1 CRISPRa kit - CRISPR gene activation of human RAD9-HUS1-RAD1 interacting nuclear orphan 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RHNO1
• Locus ID: 83695
• Kit Components:

  GA113237G1, RHNO1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113237G2, RHNO1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113237G3, RHNO1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252499, NM_001252500, NM_001257097, NM_001257098, NM_031465, NR_027363, NR_027364, NR_027365, NR_046432, NR_046433
• Synonyms: C12orf32; HKMT1188; RHINO
• Summary: Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. [UniProtKB/Swiss-Prot Function]