Human ITCH activation kit by CRISPRa

CAT#: GA113254

ITCH CRISPRa kit - CRISPR gene activation of human itchy E3 ubiquitin protein ligase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITCH
• Locus ID: 83737
• Kit Components:

  GA113254G1, ITCH gRNA vector 1 in pCas-Guide-CRISPRa

  GA113254G2, ITCH gRNA vector 2 in pCas-Guide-CRISPRa

  GA113254G3, ITCH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001257137, NM_001257138, NM_031483, NM_001324197, NM_001324198
• Synonyms: ADMFD; AIF4; AIP4; dJ468O1.1; NAPP1
• Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]