Human SVH (ARMC10) activation kit by CRISPRa

CAT#: GA113267

ARMC10 CRISPRa kit - CRISPR gene activation of human armadillo repeat containing 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARMC10
• Locus ID: 83787
• Kit Components:

  GA113267G1, ARMC10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113267G2, ARMC10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113267G3, ARMC10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161009, NM_001161010, NM_001161011, NM_001161012, NM_001161013, NM_031905
• Synonyms: PNAS-112; PNAS112; PSEC0198; SVH
• Summary: This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]