Human NCALD activation kit by CRISPRa

CAT#: GA113330

NCALD CRISPRa kit - CRISPR gene activation of human neurocalcin delta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCALD
• Locus ID: 83988
• Kit Components:

  GA113330G1, NCALD gRNA vector 1 in pCas-Guide-CRISPRa

  GA113330G2, NCALD gRNA vector 2 in pCas-Guide-CRISPRa

  GA113330G3, NCALD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040624, NM_001040625, NM_001040626, NM_001040627, NM_001040628, NM_001040629, NM_001040630, NM_032041
• Synonyms: MGC33870; MGC74858
• Summary: This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]