Human KREMEN1 activation kit by CRISPRa

CAT#: GA113335

KREMEN1 CRISPRa kit - CRISPR gene activation of human kringle containing transmembrane protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KREMEN1
• Locus ID: 83999
• Kit Components:

  GA113335G1, KREMEN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113335G2, KREMEN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113335G3, KREMEN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039570, NM_001039571, NM_032045, NM_153379
• Synonyms: KREMEN; KRM1
• Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]