Human Dysbindin (DTNBP1) activation kit by CRISPRa

CAT#: GA113346

DTNBP1 CRISPRa kit - CRISPR gene activation of human dystrobrevin binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DTNBP1
• Locus ID: 84062
• Kit Components:

  GA113346G1, DTNBP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113346G2, DTNBP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113346G3, DTNBP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271667, NM_001271668, NM_001271669, NM_032122, NM_183040, NM_183041, NR_036448
• Synonyms: BLOC1S8; DBND; HPS7; My031; SDY
• Summary: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]