Human PHD finger protein 6 (PHF6) activation kit by CRISPRa

CAT#: GA113491

PHF6 CRISPRa kit - CRISPR gene activation of human PHD finger protein 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PHF6
• Locus ID: 84295
• Kit Components:

  GA113491G1, PHF6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113491G2, PHF6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113491G3, PHF6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001015877, NM_032335, NM_032458
• Synonyms: BFLS; BORJ; CENP-31
• Summary: This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010]