Human CARD11 activation kit by CRISPRa

CAT#: GA113541

CARD11 CRISPRa kit - CRISPR gene activation of human caspase recruitment domain family member 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CARD11
• Locus ID: 84433
• Kit Components:

  GA113541G1, CARD11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113541G2, CARD11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113541G3, CARD11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001324281, NM_032415
• Synonyms: BENTA; BIMP3; CARMA1; IMD11; PPBL
• Summary: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]