Human MEGF10 activation kit by CRISPRa

CAT#: GA113565

MEGF10 CRISPRa kit - CRISPR gene activation of human multiple EGF like domains 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MEGF10
• Locus ID: 84466
• Kit Components:

  GA113565G1, MEGF10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113565G2, MEGF10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113565G3, MEGF10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256545, NM_001308119, NM_001308121, NM_032446
• Synonyms: EMARDD
• Summary: This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]