Human ZC3H8 activation kit by CRISPRa

CAT#: GA113581

ZC3H8 CRISPRa kit - CRISPR gene activation of human zinc finger CCCH-type containing 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZC3H8
• Locus ID: 84524
• Kit Components:

  GA113581G1, ZC3H8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113581G2, ZC3H8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113581G3, ZC3H8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032494
• Synonyms: Fliz1; ZC3HDC8
• Summary: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. [UniProtKB/Swiss-Prot Function]