Human BEX2 activation kit by CRISPRa

CAT#: GA113669

BEX2 CRISPRa kit - CRISPR gene activation of human brain expressed X-linked 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BEX2
• Locus ID: 84707
• Kit Components:

  GA113669G1, BEX2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113669G2, BEX2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113669G3, BEX2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168399, NM_001168400, NM_001168401, NM_032621
• Synonyms: BEX1; DJ79P11.1
• Summary: This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]