Human HRP2 (HDGFRP2) activation kit by CRISPRa

CAT#: GA113672

HDGFL2 CRISPRa kit - CRISPR gene activation of human HDGF like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HDGFL2
• Locus ID: 84717
• Kit Components:

  GA113672G1, HDGFL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113672G2, HDGFL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113672G3, HDGFL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001520, NM_032631, NM_001348169
• Synonyms: HDGF-2; HDGF2; HRP-2
• Summary: This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]