Human IL17RC activation kit by CRISPRa

CAT#: GA113706

IL17RC CRISPRa kit - CRISPR gene activation of human interleukin 17 receptor C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL17RC
• Locus ID: 84818
• Kit Components:

  GA113706G1, IL17RC gRNA vector 1 in pCas-Guide-CRISPRa

  GA113706G2, IL17RC gRNA vector 2 in pCas-Guide-CRISPRa

  GA113706G3, IL17RC gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001203263, NM_001203264, NM_001203265, NM_032732, NM_153460, NM_153461, NM_153462, NM_153463, NR_037807, NM_001367278, NM_001367279, NM_001367280
• Synonyms: CANDF9; IL17-RL; IL17RL
• Summary: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]