Human TIM 3 (HAVCR2) activation kit by CRISPRa

CAT#: GA113725

HAVCR2 CRISPRa kit - CRISPR gene activation of human hepatitis A virus cellular receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HAVCR2
• Locus ID: 84868
• Kit Components:

  GA113725G1, HAVCR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113725G2, HAVCR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113725G3, HAVCR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032782
• Synonyms: CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
• Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]