Human RSPO3 activation kit by CRISPRa

CAT#: GA113727

RSPO3 CRISPRa kit - CRISPR gene activation of human R-spondin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RSPO3
• Locus ID: 84870
• Kit Components:

  GA113727G1, RSPO3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113727G2, RSPO3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113727G3, RSPO3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032784
• Synonyms: CRISTIN1; PWTSR; THSD2
• Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]