Human ORAI1 activation kit by CRISPRa

CAT#: GA113733

ORAI1 CRISPRa kit - CRISPR gene activation of human ORAI calcium release-activated calcium modulator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ORAI1
• Locus ID: 84876
• Kit Components:

  GA113733G1, ORAI1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113733G2, ORAI1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113733G3, ORAI1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_032790
• Synonyms: CRACM1; IMD9; ORAT1; TAM2; TMEM142A
• Summary: The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]