Human HPS4 activation kit by CRISPRa

CAT#: GA113927

HPS4 CRISPRa kit - CRISPR gene activation of human HPS4 biogenesis of lysosomal organelles complex 3 subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HPS4
• Locus ID: 89781
• Kit Components:

  GA113927G1, HPS4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113927G2, HPS4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113927G3, HPS4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022081, NM_152840, NM_152841, NM_152842, NM_152843, NR_073135, NR_073136, NM_001349896, NM_001349898, NM_001349899, NM_001349900, NM_001349901, NM_001349902, NM_001349903, NM_001349904, NM_001349905, NR_146311, NR_146312, NR_146313, NR_146314, NR_146315, NR_146316
• Synonyms: LE
• Summary: This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]