HPS4 Human Gene Knockout Kit (CRISPR)

CAT#: KN409000

HPS4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: HPS4
• Locus ID: 89781
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_022081, NM_152840, NM_152841, NM_152842, NM_152843, NR_073135, NR_073136, NM_001349896, NM_001349898, NM_001349899, NM_001349900, NM_001349901, NM_001349902, NM_001349903, NM_001349904, NM_001349905, NR_146311, NR_146312, NR_146313, NR_146314, NR_146315, NR_146316
• Synonyms: LE
• Summary: This gene encodes a protein component of biogenesis of lysosome-related organelles complexes (BLOC). BLOC complexes are important for the formation of endosomal-lysosomal organelles such as melanosomes and platelet dense granules. Mutations in this gene result in subtype 4 of Hermansky-Pudlak syndrome, a form of albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]