Human CHRFAM7A activation kit by CRISPRa

CAT#: GA113936

CHRFAM7A CRISPRa kit - CRISPR gene activation of human CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRFAM7A
• Locus ID: 89832
• Kit Components:

  GA113936G1, CHRFAM7A gRNA vector 1 in pCas-Guide-CRISPRa

  GA113936G2, CHRFAM7A gRNA vector 2 in pCas-Guide-CRISPRa

  GA113936G3, CHRFAM7A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_139320, NM_148911
• Synonyms: CHRNA7; CHRNA7-DR1; D-10
• Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]