CHRFAM7A Human Gene Knockout Kit (CRISPR)
CAT#: KN407623
CHRFAM7A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.
KN2.0 knockout kit validation
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 linear donor |
Donor DNA | EF1a-GFP-P2A-Puro |
Symbol | CHRFAM7A |
Locus ID | 89832 |
Disclaimer | The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_139320, NM_148911 |
Synonyms | CHRNA7; CHRNA7-DR1; D-10 |
Summary | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] |
Documents
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN207623 | CHRFAM7A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN207623BN | CHRFAM7A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN207623LP | CHRFAM7A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
KN207623RB | CHRFAM7A - human gene knockout kit via CRISPR, HDR mediated |
USD 1,290.00 |
|
GA113936 | CHRFAM7A CRISPRa kit - CRISPR gene activation of human CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion |
USD 1,290.00 |
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